Human and Mouse Comprehensively study the role of astrocytes, microglia and oligodendrocytes in healthy and diseased samples with the Glial Profiling panel. The 770 genes on this panel cover glial cell biology that is involved in both homeostasis and disease. Study key pathways such as Cell Stress & Damage Response, Glial Regulation, Inflammation & Peripheral Immune Invasion, Glial Homeostasis & Activation and Neurotransmission. This panel is a powerful tool in the search for gene expression changes in a variety of neuroscience applications.
Glial Profiling
01 Profile 770 genes across over 50 pathways involved in glial cell biology 02 Quantify the abundance of 5 Central Nervous System cell types and 14 peripheral immune cells in a single sample 03 Study the function and interaction of glial cells with other genes involved in key pathways of neuroimmunology
Benefits
There is a complex interplay between glial cells, peripheral immune cells and neurons associated with neurodegenerative & neuroinflammatory disorders and neurotrauma such as stroke, spinal cord injury or TBI. The nCounter Glial Profiling Panel enables rapid and comprehensive analysis of astrocytes, microglia and oligodendrocytes to assess the impact of these indications on brain tissue. Genes included in the Glial Profiling panel profile unique cell profiling data for measuring the relative abundance of 5 central nervous system cells and 14 peripheral immune cell types in a single sample. Fill out this form and one of our scientists will contact you.
Details & Data
Neurodegeneration, Neuroinflammation and Traumatic Brain Injury
Cell Stress & Damage Response
127 Human/134 Mouse genesGlial Regulating Pathways
178 Human/180 Mouse genesInflammation & Peripheral Immune Invasion
187 Human/188 Mouse genesGlial Cell Homeostasis & Activation
317 Human/310 Mouse genesNeurotransmission
215 Human/211 Mouse genes
Angiogenesis Calcium Signaling Antigen Processing & Presentation Ai Astrocyte Microglial Markers Cannabinoid Signaling
Apoptosis Circadian Signaling Cell Migration A2 Astrocyte Myelogenesis Cholinergic Synapse
Autophagy Insulin Signaling Chemokines Astrocyte Differentiation/Function Neurotrophin Signaling Dopaminergic Synapse
Cell Cycle Ion Transport Complement System Astrocyte Markers Oligodendrocyte Differentiation/Maturation GABAergic Synapse
Hypoxia JAK-STAT Cytokines Blood Brain Barrier Oligodendrocyte Markers Gultamatergic Synapse
NO Metabolism & Signaling Lipid Metabolism Inflammasome Cytoskeletal Dynamics Primed Mircoglia Neuroactive Ligands & Receptors
Oxidative & Nitrosative Stress MAPK & MI3K Interferon Signaling GAP Junction Stage 1 DAM Nerogenesis
Proteotoxic Stress TGF-Beta Signaling NK-kappaB Signaling Glucose Metabolism Stage 2 DAM Neuronal Markers
Wnt Signaling Phagosytosis Homeostatic Microglia Pulnergic Signaling
T Cell Signaling Microglia Nerodegenerative Phenotype (MHnD) Serotonergic Synapse
Cell Function: Assessing abundance of CNS and Peripheral Immune Cells
Cell Type Summary # of genes
Astrocytes 8
B cells 9
CD45+ cells 1
CD8T cells 2
Cytotoxic cells 10
Dendritic cells 3
Endothelial cells 9
Exhausted CD8 4
Macrophages/Microglia 10
Mast Cells 4
Neurons 6
Neutrophils 7
NK CD56dim cells 4
NK cells 2
Oligodendrocytes 15
T cells 6
Th1 cells 1
Treg 1
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