Stem Cell Characterization

Human and Mouse

The Stem Cell Characterization nCounter panel is comprised of 770 genes covering key applications of stem cell research: Cellular Therapy, Regenerative Medicine, and Manufacturing. It is becoming a key tool in studying stem cells, stem cell therapy and differentiation. Stem cell therapy is a rapidly advancing field with applications across a broad range of research areas including neuroscience, cardiology, autoimmunity, ophthalmology, and oncology. Deeply characterize and optimize stem cell development with this panel- measuring essential components of stem cell biology. Evaluate viability, confirm functionality, determine pluripotency, assess stem cell health during production and easily detect contamination in your cell culture conditions with a single assay.



Directly profile 770 genes involved in 8 key themes of stem cell biology


Characterize stem cells during development; confirm pluripotency, understand reprogramming failures, and assess activation/differentiation


Screen for and confirm cell viability


Confirm expanded cell function via cell signaling and activation pathways

Details & Data

Challenges and Standardization

There are a number of challenges associated with culturing stem cells. This panel enables scientists to deeply characterize ESCs and iPSCs, optimizing their research on these cells. You can evaluate viability, confirm functionality and determine pluripotency with this panel. In addition, you can assess stem cell health during production and easily detect mycoplasma contamination in your cell culture conditions. These key uses offer the ability to standardize and streamline your workflow when working with stem cells.

The Stem Cell Therapy Workflow

Culturing stem cells is a delicate art — the environment needs to be tightly controlled and the cells must be checked at each stage to ensure they are differentiating as planned. The Stem Cell Characterization panel can be used throughout the development process to confidently characterize stem cells and understand pluripotency.

Functional Annotations

The Stem Cell Characterization panel provides a comprehensive view of a stem cell’s life cycle. Probes cover all 8 essential components of stem cell biology.

Stem Cell Self RenewalPluripotencyRegulatory SignalingEpigenetics MechanismsMechano-SignalingMetabolismDifferentiation SignalingLineage Specification
Stem Cell ProliferationPSC Pluripotency Markers and RegulatorsWnt/B-catenin PathwayDNA MethylationRho/ROCK SignalingOxidative Stress ResponseTGFB SignalingEndodermal/Ectodermal/Mesodermal Lineage Markers
Cell CycleNaive State/ Primed StateHedgehog SignalingAcetylation & MethylationIntegrin/Cadherin SignalingHypoxia ResponseCytoskeletal ReorganizationEctodermal/Mesodermal Lineage Markers
Senescence/QuinescenceAP-1 SignalingHippo PathwayAmino Acid MetabolismMET/EMT SignalingKey Somatic cell types
AutophagyPI3K-AKT-mTor PathwayFatty Acid MetabolismHOX Gene Activation
ApoptosisMAPK SignalingGlutamine Metabolism
Anti-ApoptosisJAK/STAT PathwayGlucose Metabolism
Notch Signaling

Contamination and Detection

Mycoplasma is a common contaminant in cultured cells. Mycoplasma can be especially problematic for stem cells as it competes for nutrients and can have a profound impact on global gene expression levels within the cells. This panel contains a probe to detect mycoplasma contamination, allowing for a quick and easy detection method.

Genes in panel

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Stem Cell Characterization



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