Resource Center

App Note/Tech Note

Using the ROSALIND Platform to Accelerate Single-Cell Data Analysis

FAQ

Gene Expression Profiling: Evaluating RNA Quality from FFPE Samples

FAQ

Selecting a CRO Partner: Navigating Laboratory Accreditation

Publication

Microbeam Radiation Therapy Controls Local Growth of Radioresistant Melanoma and Treats Out-of-Field Locoregional Metastasis

Verdiana Trappetti, PhD, Marine Potez, PhD, Cristian Fernandez-Palomo, PhD, Vladislav Volarevic, Nahoko Shintani, PhD, Paolo Pellicioli, PhD, Alexander Ernst, PhD, David Haberthur, PhD, Jennifer M. Fazzari, PhD, Michael Krisch, PhD, Jean A. Laissue, MD, Robin L. Anderson, PhD, Olga A. Martin, PhD, and Valentin G. Djonov, MD

Webinar

ChipCytometry™ Multiplexing: Practical, Approachable, Spatial Biology

J. Spencer Schwarz, Canopy Biosciences

Webinar

The Persistence of (T Cell) Memory: Towards Cellular Therapy for Solid Tumors

Douglas R. Green, PhD, Chair, Department of Immunology, Co-Leader, Cancer Biology Program, St. Jude Children’s Research Hospital

Poster/Presentation

SITC 2022 – Precise spatial multiplexing in clinical breast tumor specimens with a 60-plex ChipCytometry assay

Poster/Presentation

SITC 2022 – Using Additional Morphology Markers in NanoString® GeoMx® Whole Transcriptome Atlas Assay to Assess NSCLC Tumor Subtypes

Poster/Presentation

ASHG 2022 – Custom morphology markers allow better tissue stratification to study tumor heterogeneity using NanoString® GeoMx® DSP Platform

Case Study

Profiling the Tumor Microenvironment of Neuroblastoma using ChipCytometry™

Publication

Modeling intercellular communication in tissues using spatial graphs of cells

David S. Fischer, Anna C. Schaar & Fabian J. Theis

Webinar

Realizing the Potential of Spatial Biology for a Noncanonical Model

Shaye Hagler, Ph.D., Canopy Biosciences

Webinar

Validating Antibodies for Increasingly Sensitive Quantitative Applications

Caleb Sutton, Ph.D., Canopy Biosciences

Webinar

NanoString GeoMx® as a Key Tool for Immuno-Oncology Drug Discovery

Jessica Runyon, MA, Canopy Biosciences

Webinar

Technique Talk: Developing Spatial Multiomic Maps

Webinar

Investigating Immune Regulation by Small Extracellular Vesicles to Attenuate Chronic Pain Using High-Plex Spatial Imaging

Xuan Luo, Department of Pharmacology and Physiology, Drexel University College of Medicine

Webinar

Comprehensive Gene Expression Profiling for Immuno-Oncology Applications Using the nCounter® Analysis Platform

Christian Nievera, Ph.D., Canopy Biosciences

Product Bulletin

ChipCytometry™ ZellSafe™ Chip Kits

Product Bulletin

ChipCytometry™ CellScape™ Chip Kits

Webinar

Spatial Profiling of Neuroscience Samples Unlocks Pathways to Neurodegenerative Diseases

Jessica Runyon, M.A, Canopy Biosciences

App Note/Tech Note

Discover Novel Predictive Biomarkers with GeoMx® DSP

Webinar

Generating Actionable Spatial Biology Data with CellScape™ Precise Spatial Multiplexing

J. Spencer Schwarz, Canopy Biosciences

Poster/Presentation

AGBT 2022 – Precise spatial multiplexing of immune cell diversity in clinical breast tumor specimens with ChipCytometry

Product Bulletin

ChipCytometry™ T Cell Assay Kit

Product Bulletin

ChipCytometry™ Spatial Immune Profiling Assay Kit

Webinar

Fast Track to Precise Spatial Multiplexing: ChipCytometry™ Assay Kits and Assay Development Guidelines

Karen Kwarta, Ph.D., Canopy Biosciences

App Note/Tech Note

Using the nCounter® Platform for High-Throughput Analysis in Neuroscience Applications

Webinar

Novel Opportunities to Extend the Clinical Potential of Microbeam Radiotherapy

Olga Martin, Ph.D., Institute of Anatomy, University of Bern

Publication

ChipCytometry™ for multiplexed detection of protein and mRNA markers on human FFPE tissue samples

Sebastian Jarosch, Jan Köhlen, Sabrina Wagner, Elvira D’Ippolito, and Dirk H. Busch

Poster/Presentation

Immunology 2022 – Precise Spatial Multiplexing of Immune Cell Diversity in Clinical Tumor Samples with ChipCytometry™

Product Bulletin

ChipCytometry™ Pre-Validated Antibody List – Non-Human Primate Samples

Product Bulletin

ChipCytometry™ Pre-Validated Antibody List – Human Cell Suspension

Product Bulletin

ChipCytometry™ Pre-Validated Antibody List – Human Tissue

Product Bulletin

ChipCytometry™ Pre-Validated Antibody List – Mouse Cell Suspension

Product Bulletin

ChipCytometry™ Pre-Validated Antibody List – Mouse Tissue

Webinar

Using the nCounter® Platform for High-Throughput Transcriptomics in Neuroscience Applications

Christian Nievera, Ph.D., Canopy Biosciences

Poster/Presentation

SITC 2021 – Precise Spatial Multiplexing for Immune Profiling in Non Small Cell Lung Cancer FFPE Samples with ChipCytometry™

Poster/Presentation

CYTO 2021 – Precise Spatial Multiplexing of Immune Populations in Human Colorectal Cancer FFPE Samples with ChipCytometry™

App Note/Tech Note

nCounter® Host Response Panel for Infectious Disease Research

Webinar

Spatial Biology in Physiology and Pathology

Elana Fertig, Ph.D., Johns Hopkins University | Sanjar Srivatsan, Ph.D., University of Washington

Webinar

Multi-omics Approaches for Neurobiology Research

Webinar

Capturing Heterogeneity: How Single Cell Analysis Reshapes Health and Disease Research

Timothy O'Sullivan, Ph.D, University of California, Los Angeles | Jacob Blum, Stanford University

Webinar

Human immune cell compartments in the spleen of humanized mice

Prof. Christian Münz, Institute of Experimental Immunology, University of Zürich

Webinar

Analysis of T cell subsets in human tissue using ChipCytometry™

Prof. Paul Klenerman, Oxford University

Webinar

The Influence of Rare Cells in the Nervous System

Sebastian Lewandowski, Ph.D, Karolinska University | Philip Hasel, Ph.D., NYU School of Medicine

Webinar

High-plex immune profiling of clinical PBMCs using ChipCytometry™ – Addressing challenges with clinical sample logistics

Tim Sindelar, M.S., Canopy Biosciences

Webinar

Autoantibodies against Type I IFN found to impact morbidity when infected with COVID-19

Jessica Runyon, M.A, Canopy Biosciences

Poster/Presentation

AACR 2022 – Precise Spatial Multiplexing for Immune Profiling in FFPE Tissues with ChipCytometry™

Webinar

Precise Spatial Multiplexing for Quantitative Single-Cell Phenotyping in Tissues

Thomas Campbell, Ph.D., Canopy Biosciences

FAQ

RNA-Seq or nCounter®? Key Considerations for Gene Expression Studies

App Note/Tech Note

Developing ROI Selection Markers for GeoMx® Digital Spatial Profiling

Product Bulletin

ROI Selection Markers and CRO Services for GeoMx® Digital Spatial Profiling

Webinar

Using Spatial Transcriptomics Platforms to Assess Immune Profiling and Enable Biomarker Discovery: NanoString® GeoMx® Case Studies

Jessica Runyon, M.A, Canopy Biosciences

Webinar

Seeing is Believing: The Power of ChipCytometry™ Multiplexing

J. Spencer Schwarz, M.S., CanopyBiosciences

Webinar

Multiplexed Imaging & Automated Signal Quantification

Sebastian Jarosch, M.Sc., Institute for Immunology, Technical University of Munich (TUM)

Webinar

A Spotlight on T Cell Exhaustion

Brochure

CellScape Brochure

Webinar

Spatial Fest 2022: Exploring the Landscape with ChipCytometry™

Thomas Campbell, Ph.D, Canopy Biosciences | Sebastian Jarosch, M.Sc., Technical University of Munich (TUM) | Sarah Harris, Bristol Myers Squibb | Rachel Maddux, Ph.D, Bristol Myers Squibb | J. Spencer Schwarz, M.S., Canopy Biosciences

App Note/Tech Note

Optimizing Collection of Clinical Blood Samples for ChipCytometry™

Publication

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko Kunii, Kristy G. Kuplast-Barr, Bin Gui, Alvin Z. Lu, Jennifer R. Molina, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Mario Niepel, Zacharenia A. Varsamis, Sunaina P. Nayak, Ellen Bamberg, Jan-Rung Mo, W. David Church, Ahmed S.A. Mady, Jeff Song, Luke Utley, Patricia E. Rao, Timothy J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, and Heike Keilhack

Publication

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells

Martin J. Lett, Hema Mehta, Adrian Keogh, Tina Jaeger, Maxime Jacquet, Kate Powell, Marie-Anne Meier, Isabel Fofana, Hassan Melhem, Jürg Vosbeck, Gieri Cathomas, Andres Heigl, Markus H. Heim, Emanuel Burri, Kirsten D. Mertz, Jan Hendrik Niess, Otto Kollmar, Christoph J. Zech, Robert Ivanek, Urs Duthaler, Paul Klenerman, Deborah Stroka, Magdalena Filipowicz Sinnreich

Publication

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Tracey McLaughlin, Ingela Schnittger, Anna Naggy, Elizabeth Zanley, Yue Xu, Yanqui Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks

App Note/Tech Note

Antibody Validation for ChipCytometry™

Publication

Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry™

Sebastian Jarosch, Jan Köhlen, Rim S.J. Sarker, Katja Steiger, Klaus-Peter Janssen, Arne Christians, Christian Hennig, Ernst Holler, Elvira D'Ippolito, and Dirk H. Busch

App Note/Tech Note

Selecting a Laboratory to Support Your Clinical Trial

Brochure

Canopy CLIA Services Brochure

Product Bulletin

ChipCytometry™ Assay Catalog

Product Bulletin

CRO Services for Spatial Transcriptomics

App Note/Tech Note

Rare Cell Discovery with ChipCytometry™

Poster

Novartis — ChipCytometry™ identifies the presence of uncommon B-cell subsets in inflamed tonsils associated with autoimmunity

Publication

Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis

Lennart M Roesner, Annice Heratizadeh, Gabriele Begemann, Petra Kienlin, Susanne Hradetzky, Margarete Niebuhr, Britta Eiz-Vesper, Christian Hennig, Gesine Hansen, Véronique Baron-Bodo, Philippe Moingeon, Thomas Werfel

Webinar

Multiplex Proteomics for Immune Profiling

Publication

Human intestinal tissue-resident memory T cells comprise transcriptionally and functionally distinct subsets

Michael E.B. FitzPatrick, Nicholas M. Provine, Lucy C. Garner, ..., Elizabeth Soilleux, Paul Klenerman, Philip J. Allan

Webinar

CLIA Certification in Biomarker Analysis

Webinar

NanoString — 800 genes, 1 sample

Poster

Fraunhofer ITEM — Cellular analysis of induced sputum by ChipCytometry

Publication

Differential expression patterns of glycosphingolipids and C-type lectin receptors on immune cells in absence of functional regulatory T cells

Adan C. Jirmo, Charlotte Rossdam, Ruth Grychto, Christine Happle, Rita Gerardy-Schahn, Falk F. R. Buettner, Gesine Hansen

Webinar

ROSALIND Interactive Analysis Platform

Infographic

How NanoString Works

Publication

Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice

Jelena Skuljec, Maciej Cabanski, Ewa Surdziel, Nico Lachmann, Sebastian Brennig, Refik Pul, Adan C Jirmo, Anika Habener, Julia Visic, Kathleen Dalüge, Christian Hennig, Thomas Moritz, Christine Happle, Gesine Hansen

Publication

Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus

Marat Khodoun, Ameet A. Chimote, Farhan Z. Ilyas, Heather J. Duncan, Halima Moncrieffe, K. Shashi Kant, Laura Conforti

Webinar

Clinical ChipCytometry™ — Biobanking PBMCs for Protein Biomarker Analysis in Clinical Trials

Publication

In-Depth Immune-Oncology Studies of the Tumor Microenvironment in a Humanized Melanoma Mouse Model

Jonathan Schupp, Arne Christians, Niklas Zimmer, Lukas Gleue, Helmut Jonuleit, Mark Helm andAndrea Tuettenberg

Publication

Lung function and inflammation during murine Pseudomonas aeruginosa airway infection

Florian Wölbeling, Antje Munder, Tanja Kerber-Momot, Detlef Neumann, Christian Hennig, Gesine Hansen, Burkhard Tümmler, Ulrich Baumann

Poster

Merk — Detection of PD-L1 and PD-L2 on circulating tumor cells using ChipCytometry

Publication

A preliminary study for the assessment of PD-L1 and PD-L2 on circulating tumor cells by microfluidic-based chipcytometry

Jinkai Teo, Anja Mirenska, Meihui Tan, Yifang Lee, Janice Oh, Lewis Z Hong, Richard Wnek, Yoon-Sim Yap, Shian-Jiun Shih, Ali Asgar S Bhagat, Chih-Liang Chin & David AG Skibinski

Poster

Dynavax — Pharmacodynamic changes confirm the mechanism of action mediating SD-101 efficacy, in combination with pembrolizumab, in a phase 1b/2 study in metastatic melanoma

Publication

Long-term in vivo microscopy of CAR T cell dynamics during eradication of CNS lymphoma in mice

Matthias Mulazzani, Simon P. Fräßle, Iven von Mücke-Heim, Sigrid Langer, Xiaolan Zhou, Hellen Ishikawa-Ankerhold, Justin Leube, Wenlong Zhang, Sarah Dötsch, Mortimer Svec, Martina Rudelius, Martin Dreyling, Michael von Bergwelt-Baildon, Andreas Straube, Veit R. Buchholz, Dirk H. Busch, and Louisa von Baumgarten

Publication

Successful treatment of autoimmune and lymphoproliferative complications of patients with intrinsic B-cell immunodeficiencies with Rituximab

Christian Hennig, Ulrich Baumann, Claudia Ilginus, Gerd Horneff, Juergen Foell, Gesine Hansen

Poster

AstraZeneca/MedImmune — Comparison of human whole blood FC to ChipCytometry™

Webinar

Canopy & NanoString Spatial Biology Day

Jessica Runyon, M.A, Canopy Biosciences | Gokhan Demirkan, NanoString Technologies

Publication

Immunophenotyping of cerebrospinal fluid cells by Chipcytometry™

Martin W. Hümmert, Sascha Alvermann, Stefan Gingele, Catharina C. Gross, Heinz Wiendl, Anja Mirenska, Christian Hennig & Martin Stangel

Poster

Takeda — High-parameter profiling of psoriatic tissue

Webinar

From Mice to Men: Transition from Mouse Research to the Clinic

Sheri Barnes, Covance | Brenda Finney, ProPath UK | Ajay Pandita, Canopy Biosciences

Publication

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis

Christine Happle, Nico Lachmann, Jelena Škuljec, Martin Wetzke, Mania Ackermann, Sebastian Brennig, Adele Mucci, Adan Chari Jirmo, Stephanie Groos, Anja Mirenska, Christina Hennig, Thomas Rodt, Jens P. Bankstahl, Nicolaus Schwerk, Thomas Moritz, and Gesine Hansen

Publication

Quantitative analysis of endotoxin-induced inflammation in human lung cells by Chipcytometry™

Saskia Carstensen, Olaf Holz, Jens M. Hohlfeld, Meike Müller

Webinar

A Multi-Omic Approach to Immune Profiling

Webinar

Three Challenges with Highly Multiplexed Spatial Proteomics in Clinical Tissue Samples

J. Spencer Schwarz, M.S., Thomas Campbell, Ph.D., CanopyBiosciences

Publication

Gain-of-function STAT1 mutations are associated with intracranial aneurysms

Mete Dadak, Roland Jacobs, Jelena Skuljec, Adan Chari Jirmo, Özlem Yildiz, Frank Donnerstag, Niklas Thomas Baerlecken, Reinhold Ernst Schmidt, Heinrich Lanfermann, Thomas Skripuletz, Philipp Schwenkenbecher, Christoph Kleinschnitz, Hayrettin Tumani, Martin Stangel, Refik Pul

Poster

Trillium Therapeutics — Intralesional administration of the CD47 antagonist TTI-621 (SIRPαFc) induces responses in bothinjected and non-injected lesions in patients with relapsed/refractory mycosis fungoides and Sézary Syndrome: Interim results of a multicenter phase I trial