Glial Profiling
Human and Mouse
Comprehensively study the role of astrocytes, microglia and oligodendrocytes in healthy and diseased samples with the Glial Profiling panel. The 770 genes on this panel cover glial cell biology that is involved in both homeostasis and disease. Study key pathways such as Cell Stress & Damage Response, Glial Regulation, Inflammation & Peripheral Immune Invasion, Glial Homeostasis & Activation and Neurotransmission. This panel is a powerful tool in the search for gene expression changes in a variety of neuroscience applications.
Benefits
01
Profile 770 genes across over 50 pathways involved in glial cell biology
02
Quantify the abundance of 5 Central Nervous System cell types and 14 peripheral immune cells in a single sample
03
Study the function and interaction of glial cells with other genes involved in key pathways of neuroimmunology
Details & Data
Neurodegeneration, Neuroinflammation and Traumatic Brain Injury
There is a complex interplay between glial cells, peripheral immune cells and neurons associated with neurodegenerative & neuroinflammatory disorders and neurotrauma such as stroke, spinal cord injury or TBI. The nCounter Glial Profiling Panel enables rapid and comprehensive analysis of astrocytes, microglia and oligodendrocytes to assess the impact of these indications on brain tissue.
Cell Stress & Damage Response 127 Human/134 Mouse genes | Glial Regulating Pathways 178 Human/180 Mouse genes | Inflammation & Peripheral Immune Invasion 187 Human/188 Mouse genes | Glial Cell Homeostasis & Activation 317 Human/310 Mouse genes | Neurotransmission 215 Human/211 Mouse genes |
|
---|---|---|---|---|---|
Angiogenesis | Calcium Signaling | Antigen Processing & Presentation | Ai Astrocyte | Microglial Markers | Cannabinoid Signaling |
Apoptosis | Circadian Signaling | Cell Migration | A2 Astrocyte | Myelogenesis | Cholinergic Synapse |
Autophagy | Insulin Signaling | Chemokines | Astrocyte Differentiation/Function | Neurotrophin Signaling | Dopaminergic Synapse |
Cell Cycle | Ion Transport | Complement System | Astrocyte Markers | Oligodendrocyte Differentiation/Maturation | GABAergic Synapse |
Hypoxia | JAK-STAT | Cytokines | Blood Brain Barrier | Oligodendrocyte Markers | Gultamatergic Synapse |
NO Metabolism & Signaling | Lipid Metabolism | Inflammasome | Cytoskeletal Dynamics | Primed Mircoglia | Neuroactive Ligands & Receptors |
Oxidative & Nitrosative Stress | MAPK & MI3K | Interferon Signaling | GAP Junction | Stage 1 DAM | Nerogenesis |
Proteotoxic Stress | TGF-Beta Signaling | NK-kappaB Signaling | Glucose Metabolism | Stage 2 DAM | Neuronal Markers |
Wnt Signaling | Phagosytosis | Homeostatic Microglia | Pulnergic Signaling | ||
T Cell Signaling | Microglia Nerodegenerative Phenotype (MHnD) | Serotonergic Synapse |
Cell Function: Assessing abundance of CNS and Peripheral Immune Cells
Genes included in the Glial Profiling panel profile unique cell profiling data for measuring the relative abundance of 5 central nervous system cells and 14 peripheral immune cell types in a single sample.
Cell Type Summary | # of genes |
---|---|
Astrocytes | 8 |
B cells | 9 |
CD45+ cells | 1 |
CD8T cells | 2 |
Cytotoxic cells | 10 |
Dendritic cells | 3 |
Endothelial cells | 9 |
Exhausted CD8 | 4 |
Macrophages/Microglia | 10 |
Mast Cells | 4 |
Neurons | 6 |
Neutrophils | 7 |
NK CD56dim cells | 4 |
NK cells | 2 |
Oligodendrocytes | 15 |
T cells | 6 |
Th1 cells | 1 |
Treg | 1 |
Genes in panel
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