Human and Mouse For research in immuno-oncology, CAR-T cell therapy, infectious disease and drug development, the immune exhaustion panel is a multifaceted tool. Uncover the mechanisms behind T cell, B cell and NK cell exhaustion in diverse contexts, including cancer and infectious disease, with a 785 gene panel that gets you results fast. Characterize immune status, develop signatures for assessing the exhausted state, and identify novel therapeutic targets to prevent or reverse exhaustion- all with this curated panel from NanoString.
Immune Exhaustion
01 Immune cell exhaustion is a growing focus of R&D efforts in immuno-oncology 02 Understanding how and when cells become exhausted is an important topic for research 03 Immune cell exhaustion is a dysfunctional state induced by chronic exposure to target antigen or inflammatory signals 04 Persistent viruses have been known to induce immune exhaustion
Benefits
Immune exhaustion results from a complex interplay between a cell and its environment. While checkpoint molecules and particular receptor signaling pathways within T cells, B cells and NK cells are strong signals regulating exhaustion, senescence, anergy and tolerance, these states are also influenced by cytokines and signaling from other cell types. Understanding immune exhaustion in the context of the overall immune cell status is an important assessment to make in order to determine the state of dysfunction, impact of therapeutics and the ability to intervene and reverse exhaustion. Exhaustion is not the only context where an immune cell may lack effector function. As such, understanding the similarities and distinctions between states of dysfunction is key to understanding immune exhaustion. The Immune Exhaustion Panel provides comprehensive coverage of the most relevant immune checkpoints that can potentially be used to modulate the dynamics of the immune response. Chronic infections caused by viruses and other pathogens can induce immune exhaustion. The Human Exhaustion Panel includes probes for Epstein-Barr virus (EBV) and Cytomegalovirus (CMB), and the Mouse Immune Exhaustion Panel includes probes for Lymphocytic Choriomeningitis (LCMV). The panel can be supplemented with up to 55 genes of your choice with a Panel Plus spike-in for studying exhaustion in the context of different types of infectious disease. Genes included in the Immune Exhaustion Panel provide unique cell profiling data to measure the relative abundance of 14 different immune cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field of immunology. Fill out this form and one of our scientists will contact you.
Details & Data
Characterizing Immune Status
States of Effector Dysfunction
Pathway Annotation to Functional Themes
Immune Activation Immune Suppression Epigenetics Immune Status Immune Checkpoints Metabolism & Microenvironment
Antigen Presentation IL-1 Signaling NK Receptors IL-10 Signaling Epigenetic Modification Anergy CTLA4 Signaling Fatty Acid Metabolism
AP-1 Signaling IL-2 Signaling Other Interleukin Signaling Myeloid Immune Evasion B Cell Exhaustion PD1 Signaling Glutamine Metabolism
Apoptosis IL-6 Signaling PI3K-AKT Pathway Notch Signaling Naive T Cell Checkpoint Signaling Glycolysis and Glucose Import
B Cell Memory IL-7 Signaling T Cell Memory RAR Signaling NK Exhaustion Hypoxia Response
BCR Signaling JAK/STAT Signaling TCR Signaling TGF-beta Signaling Senescence & Quiescence PPAR Signaling
Cell Cycle MAPK Signaling TLR Signaling T Cell Exuastion
Chemokine Signaling mTOR Signaling TNF Signaling
Cytotoxicity NF-k8 Signaling Type I Interferon
DAP12 Signaling NK Activity Type II Interferon
Immune Checkpoint Coverage
CD28 ICOSLG LAG3 TNFSF18 ICOS
CD40 PDCD1 HAVCR2 VSIR CD70
CD80 TNFSF4 TNFSF9 CD27 CD276
CD86 CD274 TNFRSF9 CD40LG ADORA2A
CTLA4 PDCDILG2 TNFRSF18 TNFRSF4 TIGIT
Viral Identification
Immune Cell Profiling
Cell Type Human Genes Cell Type # of Human Genes
B cells BLK, CD19, FAM30A, FCRL2, MS4A1, PNOC, SPIB, TCL1A, TNFRSF17 Mast Cells CPA3, HDC, MS4A2, TPSAB1/B2
CD45+ cells PTPRC NK CD56dim cells IL21R, KIR2DL3/4, KIR3DL1/2
CD8T cells CD8A, CD8B NK cells NCR1, XCL1/2
Cytotoxic cells CTSW, GNLY, GZMA, GZMB, GZMH, KLRB1, KLRD1, KLRK1, NKG7, PRF1 Neutrophils CEACAM3, CSF3R, FCAR, FCGR3A/B, FPR1, S100A12, SIGLEC5
Dendritic cells CCL13, CD209, HSD11B1 T cells CD3D, CD3E, CD3G, CD6, SH2D1A, TRAT1
Exhausted CD8 cells CD244, EOMES, LAG3, PTGER4 Th1 cells TBX21
Macrophages CD163, CD68, CD84, MS4A4A Tregs FOXP3
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