Tumor Signaling 360

Human and Mouse

This panel covers genes involved in tumorigenesis, metastasis, and inflammation, offering a holistic view of the biology of the tumor, microenvironment and immune response. The panel emphasizes dysfunctional cell signaling and can be used to identify targets for novel therapies. Study the mechanism of action for current therapies with a comprehensive look at 40+ pathways involved in tumor biology, immune evasion and remodeling of the microenvironment.



Benefits

01

780 genes covering 40+ pathways involved in tumor signaling

02

Gain a greater understanding of the interactions of tumor cells with tissue milieu

03

Identify targets for novel therapeutics and measure anti-tumor immune response

04

Quantify the presence and relative abundance of 14 different immune cell types


Details & Data

Targeted Tumor Signaling Therapeutics

As therapeutics that target tumor signaling evolve, a greater understanding if tumor signaling is required coupled to a better understanding of the interactions of tumor cells with the tissue environment. The Tumor Signaling 360 panel enables a deeper profiling of the tumor while focusing on signaling pathways of interest for target therapeutic development. The carefully curated panel gives a 360 view of gene expression involved in the biology of the tumor, microenvironment, and the immune response.

Core Themes and Annotations

As therapeutics that target tumor signaling evolve, a greater understanding of tumor signaling is required; coupled to a better understanding of the interactions of tumor cells with the tissue environment. A greater understanding of tumor signaling is needed as therapeutic treatments evolve, often targeting this pathway. The Tumor Signaling panel specifically focuses on providing a deeper profile of the tumor, enabling a more complete picture of the signaling pathways that may be of therapeutic interest.

Tumor Signaling

Cellular Energetics
105 Human/104 Mouse genes
Sustained Proliferation
223 Human/221 Mouse genes
Evading Growth Suppressors
79 Human & Mouse genes
Enabling Replicative Immortality
48 Human & Mouse genes
Genomic Instability & Mutation
111 Human & Mouse genes
Resisting Cell Death
23 Human & Mouse genes
AutophagyAndrogen SignalingMAPK SignalingCell CycleImmortality & StemnessDNA Damage & RepairApoptosis
Glucose MetabolismEGFR SignalingMET SignalingSenescenceEpigenetic & Transcriptional RegulationTNF Superfamily
Glutamine MetabolismERBB2 SignalingMycP53 Signaling
Lipid MetabolismEstrogen SignalingNotch Signaling
mTOR SignalingFGFR SignalingPI3K-Akt Signaling
Nrd2 & Oxidative StressHedgehogTGF-beta Signaling
Wnt Signaling
Immune Evasion
122 Human/124 Mouse genes
Tumor-Promoting Inflammation
178 Human/171 Mouse genes
Antigen PresentationT cell ExhaustionChemokine Signaling
B cell FunctionTCR SignalingInflammation
CytotoxicityTumor AntigenInterferon Response
Myeloid Immune EvasionT cell Co-stimulationJAK-STAT Signalign
NF-k8 Signaling
Activating Invasion and Metastasis
146 Human & Mouse genes
Angiogenesis
67 Human & Mouse genes
Cell Adhesion & ModalityHiF1 Signaling
ECM Remodeling & MetastasisPDGF Signaling
EMTVGEF Signaling
Hippo Signaling

Immune Cell Profiling

Genes included in the Tumor Signaling 360 Panel provide unique cell profiling data to measure the relative abundance of 14 different human immune cell types. This table summarizes each cell type represented by gene content in the panel, as qualified through biostatistical approaches and selected literature in the field of immunology.

Cell TypeAssociated Human Genes
B CellsBLK, CD19, FAM30A, FCRL2, MS4A1, PNOC, SPIB, TCL1A, TNFRSF17
CD45 CellsPTPRC
CD8 CellsCD8A, CD8B
Cytotoxic CellsCTSW, GNLY, GZMA, GZMB, GZMH, KLRB1, KLRD1, KLRK1, NKG7, PRPF1
Dendritic CellsCCL13, CD209, HSD11B1
Exhausted CDCD244, EOMES, LAG3, PTGER4
MacrophagesCD163, CD68, CD84, MS4A4A
Mast CellsCPA3, HDC, MS4A2, TPSAB1/B2
NeutrophilsCEACAM3, CSF3R, FCAR, FCGR3A/B, FPR1, S100A12, SIGLEC5
NK CellsNCR1, XCL1/2
NK CD56dim CellsIL21R, KIR2DL3, KIR3DL1, KIR3DL2
T CellsCD3D, CD3E, CD3G, CD6, SH2D1A, TRAT1
Th1 CellsTBX21
TregFOXP3

Genes in panel

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Tumor Signaling 360

$5,459.00

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