Host Response

Human

Study the phases and progression of infection across the five major components of the host response with pathogen-agnostic content optimized for blood but suitable for all sample types. Profile 785 human genes across 50+ pathways, develop gene signature of immune response, and validate biomarkers for disease severity. Customize your research project by adding tissue or pathogen specific probes to truly probe host response.

Benefits

01

Customizable with Coronavirus Panel Plus to study SARS-CoV-2 and other coronaviruses.

02

Includes cell profiling data to measure the relative abundance of 14 immune cell types.

03

Probes have high homology with non-human primates, allowing for seamless comparative infectious disease research and preclinical studies.

04

Develop signatures for host response dynamics while evaluating the effects of vaccines & therapies.

Details & data

Pathogens — Immune Response Dynamics — Vaccine & Therapy Development

This panel allows you to study the 5 elements of host response:

  • Host susceptibility
  • Interferon response
  • Innate immune cell activation
  • Adaptive immune response
  • Homeostasis

Pathway Annotation Across the Five-Functions of the Host Response

Host Susceptibility
26 Genes
Interferon Response
288 Genes
Innate Immune Cell Activation
567 Genes
Adaptive Immune Response
433 Genes
Homeostasis
282 Genes
Angiotensin SystemALPK1 SignalingChemokine SignalingBCR SignalingAngiotensin System
Virus-Host InteractionDNA SensingCytoxicityComplement SystemApoptosis
Glycan SensingHost Defense PeptidesImmune ExhaustionAutophagy
InflammasomesIL-1 SignalingImmune MemoryCoagulation
Interferon Response GenesIL-2 SignalingLymphocyte TraffickingHIF1A Signaling
JAK/STAT SignalingIL-6 SignalingMHC Class I Antigen PresentationLeukotriene and Prostaglandin Inflammation
MAPK SignalingIL-7 SignalingMHC Class II Antigen PresentationLysosomes
NLR SignalingMononuclear Cell MigrationMononuclear Cell MigrationOxidative Stress Response
RNA SensingMyeloid ActivationT cell CostimulationProteotoxic Stress
TLR SignalingMyeloid InflammationTCR SignalingTissue Stress
TNF SignalingNK ActivityTH1 DifferentiationTNF Signaling
Type I Interferon SignalingNF-kappaB SignalingTH2Differentiation
Type II Interferon SignalingNO SignalingTH9 Differentiation
Type II Interferon SignalingOther Interleukin SignalingTH17 Differentiation
Oxidative Stress ResponseTreg Differentiation
Phagocytosis
PPAR Signaling
TGF-beta Signaling
TNF Signaling

Panel Customization and COVID-19 Research

The Host Response panel can be customized by adding tissue—or pathogen specific probes using the Panel Plus option. For those researching COVID-19, NanoString offers a 20-gene Coronavirus Panel Plus to study SARS-CoV-2 and other corona viruses.

COVID-19 Panel Plus Gene NameAccession NumberOfficial Name
ACE2_HsNM_021804.2angiotensin I converting enzyme 2
HCoV-229E_NHCoV229Egp7.1nucleocapsid phosphoprotrein
HCov-229E_SHCoV229Egp2.1surface glycoprotein
HCoV-HKU1_NHCHV1gp7.1nucleocapsid phosphoprotein
HCoV-HKU1_SHCHV1gp3.1surface glycloprotein
HCoV-NL63_NHCNV63gp6.1nucleocapsid phosphoprotein
HCoV-NL63_SHCNV63gp2.1surface glycoprotein
HCoV-OC43_NEYW02_gp8.1nucleocapsid phosphoprotein
HCoV-OC43_SEYW02_gp4.1surface glycoprotein
SARS-CoV_Nsars9a.1nucleocapsid phosphoprotein
SARS-CoV_Ssars2.1surface glycoprotein
SARS-CoV-2
_E
HCOV_gp4.1envelope protein
SARS-CoV-2_MHCOV_gp5.1membrane glycoprotein
SARS-CoV-2_orf1abHCOV_gp1.1orf1a polyprotein;orf1ab polyprotein
SARS-CoV-2_orf1ab_REVHCOV_gp1.1_REV.1Negative Strand: orf1a polyprotein;orf1ab polyprotein
SARS-CoV-2_ORF3aHCOV_gp3.1ORF3a protein
SARS-CoV-2_ORF7aHCOV_gp7.1ORF7a protein
SARS-CoV-2_ORF8HCOV_gp8.1ORF8 protein
SARS-CoV-2_SHCOV_gp2.1surface glycoprotein

COVID-19 Tissue Reference Gene List

Tissue specific genes for kidney, GI tract, liver, endothelium, lung, and brain can be added as a Panel Plus to the Host Response panel. Use the Tissue Reference Gene list for suggestions. Click here for the list of genes and their associated tissues.

Immune Checkpoint Coverage

This panel provides comprehensive coverage of the most relevant checkpoints to study modulation of the host immune response and subsequent inflammatory cascade.

ADORA2A (A2aR)CD70HAVCR2 (TIM3)CD274 (PD-L1)TNFRSF9 (4-1BB)
CD27CD80ICOSPDCD1LG2 (Pd-L2)TNFSF9 (4-1BBL)
CD28CD86ICOSLG (B7-H2)TIGITTNFRSF18 (GITR)
CD40CD276 (B7-H3)LAG3TNFRSF4 (OX40)TNFSF18 (GITRL)
CD40LgCTLA-4PDCD1 (PD-1)TNFSF4 (OX40L)VSIR (VISTA)

Non-Human Primate Compatibility

This panel offers high homology to non-human primates, allowing for seamless study of infectious disease in research subjects and moving to preclinical studies. The percent identify is listed below, with the higher the percentage, the higher the likelihood the probe will interact with both human and NHP species.

% IdentityCynomologus MacaqueResus Macaque
>=95%695 genes696 gemes
>=90%758 genes751 genes
>=85%772 genes772 genes

Immune Cell Profiling

Genes included in the Host Response panel provide unique cell profiling data to measure the relative abundance of 14 different human immune cell types. The table below summarizes the genes included in each cell type signature, as qualified through biostatistical approaches and selected literature in the field.

Cell TypeHuman GenesCell Type# of Human Genes
B cellsBLK, CD19, FAM30A, FCRL2, MS4A1, PNOC, SPIB, TCL1A, TNFRSF17Mast CellsCPA3, HDC, MS4A2, TPSAB1/B2
CD45+ cellsPTPRCNK CD56dim cellsIL21R, KIR2DL3, KIR3DL1/2
CD8 T cellsCD8A, CD8BNK cellsNCR1, XCL1/2
Cytotoxic cellsCTSW, GNLY, GZMA, GZMB, GZMH, KLRB1, KLRD1, KLRK1, NKG7, PRF1NeutrophilsCEACAM3, CSF3R, FCAR, FCGR3A/B, FPR1, S100A12, SIGLEC5
Dendritic cellsCCL13, CD209, HSD11B1T cellsCD3D, CD3E, CD3G, CD6, SH2D1A, TRAT1
Exhausted CD8 cellsCD244, EOMES, LAG3, PTGER4Th1 cellsTBX21
MacrophagesCD163, CD68, CD84, MS4A4ATregsFOXP3

Genes in panel

Pricing

Host Response

$5,300.00

$
Step 3

Price

Number of samples
$5,300.00*
*price includes reagents
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