Human and Mouse The Stem Cell Characterization nCounter panel is comprised of 770 genes covering key applications of stem cell research: Cellular Therapy, Regenerative Medicine, and Manufacturing. It is becoming a key tool in studying stem cells, stem cell therapy and differentiation. Stem cell therapy is a rapidly advancing field with applications across a broad range of research areas including neuroscience, cardiology, autoimmunity, ophthalmology, and oncology. Deeply characterize and optimize stem cell development with this panel- measuring essential components of stem cell biology. Evaluate viability, confirm functionality, determine pluripotency, assess stem cell health during production and easily detect contamination in your cell culture conditions with a single assay.
Stem Cell Characterization
01 Directly profile 770 genes involved in 8 key themes of stem cell biology 02 Characterize stem cells during development; confirm pluripotency, understand reprogramming failures, and assess activation/differentiation 03 Screen for and confirm cell viability 04 Confirm expanded cell function via cell signaling and activation pathways
Benefits
There are a number of challenges associated with culturing stem cells. This panel enables scientists to deeply characterize ESCs and iPSCs, optimizing their research on these cells. You can evaluate viability, confirm functionality and determine pluripotency with this panel. In addition, you can assess stem cell health during production and easily detect mycoplasma contamination in your cell culture conditions. These key uses offer the ability to standardize and streamline your workflow when working with stem cells. Culturing stem cells is a delicate art — the environment needs to be tightly controlled and the cells must be checked at each stage to ensure they are differentiating as planned. The Stem Cell Characterization panel can be used throughout the development process to confidently characterize stem cells and understand pluripotency. The Stem Cell Characterization panel provides a comprehensive view of a stem cell’s life cycle. Probes cover all 8 essential components of stem cell biology. Mycoplasma is a common contaminant in cultured cells. Mycoplasma can be especially problematic for stem cells as it competes for nutrients and can have a profound impact on global gene expression levels within the cells. This panel contains a probe to detect mycoplasma contamination, allowing for a quick and easy detection method. Fill out this form and one of our scientists will contact you.
Details & Data
Challenges and Standardization
The Stem Cell Therapy Workflow
Functional Annotations
Stem Cell Self Renewal Pluripotency Regulatory Signaling Epigenetics Mechanisms Mechano-Signaling Metabolism Differentiation Signaling Lineage Specification
Stem Cell Proliferation PSC Pluripotency Markers and Regulators Wnt/B-catenin Pathway DNA Methylation Rho/ROCK Signaling Oxidative Stress Response TGFB Signaling Endodermal/Ectodermal/Mesodermal Lineage Markers
Cell Cycle Naive State/ Primed State Hedgehog Signaling Acetylation & Methylation Integrin/Cadherin Signaling Hypoxia Response Cytoskeletal Reorganization Ectodermal/Mesodermal Lineage Markers
Senescence/Quinescence AP-1 Signaling Hippo Pathway Amino Acid Metabolism MET/EMT Signaling Key Somatic cell types
Autophagy PI3K-AKT-mTor Pathway Fatty Acid Metabolism HOX Gene Activation
Apoptosis MAPK Signaling Glutamine Metabolism
Anti-Apoptosis JAK/STAT Pathway Glucose Metabolism
Notch Signaling
Contamination and Detection
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