Human and Mouse This panel covers genes involved in tumorigenesis, metastasis, and inflammation, offering a holistic view of the biology of the tumor, microenvironment and immune response. The panel emphasizes dysfunctional cell signaling and can be used to identify targets for novel therapies. Study the mechanism of action for current therapies with a comprehensive look at 40+ pathways involved in tumor biology, immune evasion and remodeling of the microenvironment.
Tumor Signaling 360
01 780 genes covering 40+ pathways involved in tumor signaling 02 Gain a greater understanding of the interactions of tumor cells with tissue milieu 03 Identify targets for novel therapeutics and measure anti-tumor immune response 04 Quantify the presence and relative abundance of 14 different immune cell types
Benefits
As therapeutics that target tumor signaling evolve, a greater understanding if tumor signaling is required coupled to a better understanding of the interactions of tumor cells with the tissue environment. The Tumor Signaling 360 panel enables a deeper profiling of the tumor while focusing on signaling pathways of interest for target therapeutic development. The carefully curated panel gives a 360 view of gene expression involved in the biology of the tumor, microenvironment, and the immune response. As therapeutics that target tumor signaling evolve, a greater understanding of tumor signaling is required; coupled to a better understanding of the interactions of tumor cells with the tissue environment. A greater understanding of tumor signaling is needed as therapeutic treatments evolve, often targeting this pathway. The Tumor Signaling panel specifically focuses on providing a deeper profile of the tumor, enabling a more complete picture of the signaling pathways that may be of therapeutic interest. Genes included in the Tumor Signaling 360 Panel provide unique cell profiling data to measure the relative abundance of 14 different human immune cell types. This table summarizes each cell type represented by gene content in the panel, as qualified through biostatistical approaches and selected literature in the field of immunology. Fill out this form and one of our scientists will contact you.
Details & Data
Targeted Tumor Signaling Therapeutics
Core Themes and Annotations
Tumor Signaling
Cellular Energetics
105 Human/104 Mouse genesSustained Proliferation
223 Human/221 Mouse genesEvading Growth Suppressors
79 Human & Mouse genesEnabling Replicative Immortality
48 Human & Mouse genesGenomic Instability & Mutation
111 Human & Mouse genesResisting Cell Death
23 Human & Mouse genes
Autophagy Androgen Signaling MAPK Signaling Cell Cycle Immortality & Stemness DNA Damage & Repair Apoptosis
Glucose Metabolism EGFR Signaling MET Signaling Senescence Epigenetic & Transcriptional Regulation TNF Superfamily
Glutamine Metabolism ERBB2 Signaling Myc P53 Signaling
Lipid Metabolism Estrogen Signaling Notch Signaling
mTOR Signaling FGFR Signaling PI3K-Akt Signaling
Nrd2 & Oxidative Stress Hedgehog TGF-beta Signaling
Wnt Signaling
Immune Evasion
122 Human/124 Mouse genesTumor-Promoting Inflammation
178 Human/171 Mouse genes
Antigen Presentation T cell Exhaustion Chemokine Signaling
B cell Function TCR Signaling Inflammation
Cytotoxicity Tumor Antigen Interferon Response
Myeloid Immune Evasion T cell Co-stimulation JAK-STAT Signalign
NF-k8 Signaling
Activating Invasion and Metastasis
146 Human & Mouse genesAngiogenesis
67 Human & Mouse genes
Cell Adhesion & Modality HiF1 Signaling
ECM Remodeling & Metastasis PDGF Signaling
EMT VGEF Signaling
Hippo Signaling
Immune Cell Profiling
Cell Type Associated Human Genes
B Cells BLK, CD19, FAM30A, FCRL2, MS4A1, PNOC, SPIB, TCL1A, TNFRSF17
CD45 Cells PTPRC
CD8 Cells CD8A, CD8B
Cytotoxic Cells CTSW, GNLY, GZMA, GZMB, GZMH, KLRB1, KLRD1, KLRK1, NKG7, PRPF1
Dendritic Cells CCL13, CD209, HSD11B1
Exhausted CD CD244, EOMES, LAG3, PTGER4
Macrophages CD163, CD68, CD84, MS4A4A
Mast Cells CPA3, HDC, MS4A2, TPSAB1/B2
Neutrophils CEACAM3, CSF3R, FCAR, FCGR3A/B, FPR1, S100A12, SIGLEC5
NK Cells NCR1, XCL1/2
NK CD56dim Cells IL21R, KIR2DL3, KIR3DL1, KIR3DL2
T Cells CD3D, CD3E, CD3G, CD6, SH2D1A, TRAT1
Th1 Cells TBX21
Treg FOXP3
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