The MAPK and PI3K pathways control key cellular processes in development, homeostasis, and disease. A variety of extracellular signals converge on these pathways, leading to the expression of genes controlling multiple cellular and tissue-level functions. Seminal publications focused on MAPK and PI3K research and signature development were collated and scored to develop a curated gene set measuring transcriptional activity of these key pathways. This panel represents the diverse set of biological functions that the MAPK and PI3K pathways modulate as crucial mediators of biological activity.

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