Alzheimer’s Disease

Human and Mouse

Easily assess and monitor primary molecular characteristics of Alzheimer’s disease (AD) with 770 standardized genes covering 30 clinically derived AD-associated modules discovered in the AMP-AD consortium study of human brain tissue. The AD panel from NanoString allows researchers to reliably assay AD phenotypes and disease progression for mouse model development and human tissue screening.

Benefits

01

Reproducibly translate mouse models of AD to human disease with 770 standardized genes.

02

Comprehensive assessment of 30 AD-associated gene co-expression modules including 23 neurodegeneration pathways and processes.

03

Perform in vivo screening of potential therapeutics with an efficient and translational workflow to potentially reduce time to the clinic.

04

Monitor disease progression with age and characterize AD.

Details & data

AMP-AD program derived content

The content included in the Human and Mouse Alzheimer’s Disease panels represent a transcriptomic fingerprint of AD-related changes that can be directly compared to studies of mouse models of disease and back to human tissue. These pathways and processes assigned to the 770 genes included in the panels assist in providing additional insight into important aspects of the onset, progression and characterization of AD. Panel design is based on work done by the AMP-AD Consortium, a program of the Accelerating Medicines Partnership (AMP) focused on Alzheimer’s research.

Brain Region Coverage

RNA-seq was used to analyze 7 brain regions from 3 AD studies for clusters of co-expressed genes. The goal was identifying correlations with known biological functions and cell types. The annotations included in the panel represent the resulting gene expression clusters, or modules. They are named by the brain region they were discovered in and assigned a color. The content of the panel suggests co-expression of genes related to neurons, microglia and astrocytes.

Brain Region Coverage
AD-associated gene co-expression module
Neuropathology Pathway and Process represented
# of genes (both Mouse and Human)
Cerebellum (CE)CBEblueTranscription and Splicing176
CBEbrownLipid Metabolism, Myelination95
CBEturquoiseCytokines199
CBEyellowVesicle Trafficking, Transmitter Synthesis and Storage156/157
Dorsolateral prefrontal cortex (DLPFC)DLPFCblueCytokines182
DLPFCbrownLipid Metabolism, Myelination139
DLPFCturquoiseTranscription and Splicing143
DLPFCyellowTransmitter Synthesis and Storage, Vesicle Trafficking, Transmitter Release, Neural Connectivity191/193
Frontal pole (FP)FPblueLipid Metabolism, Myelination277
FPbrown77
FPturquoiseCytokines107
FPyellowVesicle Trafficking, Transmitter Synthesis and Storage, Neural Connectivity, Transmitter Release187/188
Inferior frontal gyrus (IFG)IFGblueTranscription and Splicing, Lipid Metabolism, Myelination236
IFGbrownTransmitter Synthesis and Storage, Vesicle Trafficking, Transmitter Release, Neural Connectivity232/235
IFGturquoiseApoptosis, Cytokines126
IFGyellow84
Parahippocampal gyrus (PHG)PHGblueTranscription and Splicing170
PHGbrownTransmitter Synthesis and Storage, Vesicle Trafficking164/165
PHGgreenLipid Metabolism, Myelination139
PHGturquoiseCytokines104
PHGyellow101
Superior temporal gyrus (STG)STGblueCytokines143
STGbrownTransmitter Synthesis and Storage, Vesicle Trafficking, Neural Connectivity, Transmitter Release, Transmitter Response and Reuptake210/212
STGturquoiseTranscription and Splicing118
STGyellowLipid Metabolism, Myelination159
Temporal cortex (TCX)TCXblue118
TCXbrownTranscription and Splicing124
TCXgreenTransmitter Synthesis and Storage, Vesicle Trafficking185/187
TCXturquoise78
TCXyellowLipid Metabolism152
Internal Reference Genes10

The AD-associated gene co-expression modules also cross reference to 23 fundamental pathways and processes of neuropathology. These modules and the associated number of genes on the panel are listed below.

Neuropathology Pathway and/or Process Annotation
# Human Genes
# Mouse Genes
Disease Association151150
Activated Microglia6464
Angiogenesis2626
Apoptosis88
Autophagy1616
Axon and Dendrite Structure7878
Tissue Integrity1717
Carbohydrate Metabolism1717
Chromatin Modification1719
Cytokines88
Growth Factor Signaling4546
Lipid Metabolism66
Myelination2020
Neural Connectivity9494
Neuronal Cytoskeleton55
Oxidative Stress2424
Transcription and Splicing66
Transmitter Release4746
Transmitter Response and Reuptake4645
Transmitter Synthesis and Storage1818
Trophic Factors1110
Unfolded Protein Response2122
Vesicle Trafficking6161

Genes in panel

Pricing

Alzheimer’s Disease

$4,490.00

$
Step 3

Price

Number of samples
$4,490.00*
*price includes reagents
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