AMP-AD program derived content

The content included in the Human and Mouse Alzheimer’s Disease panels represent a transcriptomic fingerprint of AD-related changes that can be directly compared to studies of mouse models of disease and back to human tissue. These pathways and processes assigned to the 770 genes included in the panels assist in providing additional insight into important aspects of the onset, progression and characterization of AD. Panel design is based on work done by the AMP-AD Consortium, a program of the Accelerating Medicines Partnership (AMP) focused on Alzheimer’s research.

Brain Region Coverage

RNA-seq was used to analyze 7 brain regions from 3 AD studies for clusters of co-expressed genes. The goal was identifying correlations with known biological functions and cell types. The annotations included in the panel represent the resulting gene expression clusters, or modules. They are named by the brain region they were discovered in and assigned a color. The content of the panel suggests co-expression of genes related to neurons, microglia and astrocytes.

The AD-associated gene co-expression modules also cross reference to 23 fundamental pathways and processes of neuropathology. These modules and the associated number of genes on the panel are listed below.