Resource Center

Brochure

CellScape Brochure

Brochure

Canopy Spatial Services Brochure

Publication

Characterization of latently infected EBV+ antibody-secreting B cells isolated from ovarian tumors and malignant ascites

Luxin Zhang, Mary Strange, Esther Elishaev, Syed Zaidi, Francesmary Modungo, Mackenzy Radolec, Robert P. Edwards, Olivera J. Finn, Anda M. Vlad

Webinar

Setting the Standard in Spatial Biology: Deciphering Tumor Characteristics in Kidney Cancer Metastases Using CellScape

Allison May, MD, Society of Urologic Oncology Fellow and Clark Family Fellow for Kidney Cancer Research, University of Michigan; Thomas Campbell, PhD, Associate Director of Product Management, Canopy Biosciences

App Note/Tech Note

Data Driven Assay Expansion

Poster/Presentation

VistaPlex Immunofluorescence Assay Panels Provide Reliable Deep Spatial Phenotyping for Diverse Immuno-Oncology Applications

Poster/Presentation

Towards a Drag and Drop Spatial Biology Workflow: Introducing Sample Reinterrogation as a Conduit for the Progressive Development and On-line Analysis of High Parameter Spatial Biology Data

Poster/Presentation

High-resolution analysis of immune checkpoint activation utilizing a combine PD1/PD-L1 in situ proximity ligation assay (isPLA) and multiplex immunofluorescence (mIF) imaging approach

Poster/Presentation

High dynamic range (HDR) microscopy optimizes assay sensitivity and dynamic range in quantitative, high-plex spatial biology applications

Poster/Presentation

A Comprehensive Analytical Validation Framework for Antibodies used in CellScape Multiplex Immunofluorescence Assay

Webinar

Exploring Complex Tissue Microenvironments With Spatial Biology

Thomas Campbell, PhD, Associate Director of Product Management, Canopy Biosciences; Matthew Ingalls, PhD, Applications Scientist — Spatial Biology, Canopy Biosciences

Webinar

Using Spatial Proteomics to Investigate the Transition From Beneficial to Maladaptive Inflammatory Tissue in Chronic Liver Disease

Nico Kraus, Scientific Manager, Clinical Research Associate, University Hospital Frankfurt

Webinar

Improving Tumor Microenvironment Proteomics Using Spatial Biology

Thomas Campbell, PhD, Canopy Biosciences

Poster/Presentation

Investigating the Molecular Architecture of Triple Positive Breast Cancer Samples with Spatial Omics Technologies

Poster/Presentation

Switchable Antibodies for Increased Throughput in Iterative Immuno-Fluorescent Staining of Cancer Tissue Using ChipCytometry™

Publication

Phase II trial of nivolumab and metformin in patients with treatmentrefractory microsatellite stable metastatic colorectal cancer

Mehmet Akce, Batoul Farran, Jeffrey M Switchenko, Manali Rupji, Sandra Kang, Lana Khalil, Amanda Ruggieri-Joyce, Brian Olson, Walid L Shaib, Christina Wu, Olatunji B Alese, Maria Diab, Greogy B Lesinski, Bassel F El-Rayes

Poster/Presentation

Spatial Multiplexing of Protein Biomarkers for Immune Cell Profiling of the Tumor Microenvironment with ChipCytometry™

Product Bulletin

VistaPlex™ Spatial Immune Profiling Assay Kit Validation Report

App Note/Tech Note

Highly Multiplexed Immune Cell Phenotyping with ChipCytometry™

Brochure

ChipCytometry™ Validated Marker List

Webinar

Spatial Multiomics Reveal Microbiome-Linked T Cell Modulations in Human Graft-Versus-Host Disease

Benton Berigan, PhD, Product Manager, Canopy Biosciences

App Note/Tech Note

Immune Profiling of Breast Cancer Tissue using CellScape

Webinar

Immune Dysregulation in Inflammatory Bowel Disease

Jiangwei Zhang, PhD Senior Principal Scientist, Bristol Myers Squibb & J. Spencer Schwarz, Product Manager, Canopy Biosciences

Webinar

Spatial Immunome of Distal Tissues During Intestinal Inflammation

Gustavo Monasterio, DDS, PhD, Postdoctoral Fellow, Villablanca Lab, Karolinska Institute

Publication

T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Daria Briukhovetska, Javier Suarez-Gosalvez, Cornelia Voigt, Anamarija Markota, Anastasios D. Giannou, Maryam Schübel, Jakob Jobst, Tao Zhang, Janina Dörr, Florian Märkl, Lina Majed, Philipp Jie Müller, Peter May, Adrian Gottschlich, Nicholas Tokarew, Jöran Lücke, Arman Oner, Melanie Schwerdtfeger, David Andreu-Sanz, Ruth Grünmeier, Matthias Seifert, Stefanos Michaelides, Michael Hristov, Lars M. König, Bruno Loureiro Cadilha, Oleg Mikhaylov, Hans-Joachim Anders, Simon Rothenfusser, Richard A. Flavell, Daniela Cerezo-Wallis, Cristina Tejedo, María S. Soengas, Tobias Bald, Samuel Huber, Stefan Endres, and Sebastian Kobold

Publication

Bispecific antibodies redirect synthetic agonistic receptor modified T cells against melanoma

Florian Märkl1, Mohamed-Reda Benmebarek, Julius Keyl1, Bruno L Cadilha, Martina Geiger, Clara Karches, Hannah Obeck, Melanie Schwerdtfeger, Stefanos Michaelides, Daria Briukhovetska, Sophia Stock, Jakob Jobst, Philipp Jie Müller, Lina Majed, Matthias Seifert, Anna-Kristina Klüver, Theo Lorenzini, Ruth Grünmeier, Moritz Thomas, Adrian Gottschlich, Richard Klaus, Carsten Marr, Michael von Bergwelt-Baildon, Simon Rothenfusser, Mitchell P Levesque, Markus Vincent Heppt, Stefan Endres, Christian Klein and Sebastian Kobold

Publication

CagA-specific Gastric CD8+ Tissue-Resident T Cells Control Helicobacter pylori During the Early Infection Phase

Maximilian R A Koch, Ruolan Gong, Verena Friedrich, Veronika Engelsberger, Lorenz Kretschmer, Andreas Wanisch, Sebastian Jarosch, Anna Ralser Bob Lugen, Michael Quante, Michael Vieth, Riccardo Vasapolli, Christian Schulz, Veit R Buchholz, Dirk H Busch, Raquel Mejías-Luque, Markus Gerhard

Publication

Multimodal immune cell phenotyping in GI biopsies reveals microbiome-related T cell modulations in human GvHD

Sebastian Jarosch, Jan Ko¨hlen, Sakhila Ghimire, ..., Elvira D’Ippolito, Ernst Holler, Dirk H. Busch

Poster/Presentation

Precise Spatial Immune Profiling of PBMC Populations Using a VistaPlex™ ChipCytometry™ Assay Kit

Poster/Presentation

Spatial Immunoprofiling of Active Celiac Disease Tissue with ChipCytometry™

Product Bulletin

CellScape™ Chip Kits for ChipCytometry™ Assays

Webinar

Immunohistochemistry and Spatial Biology: Using IHC for Next Gen Techniques

Christian Nievera, Ph.D., Canopy Biosciences

Webinar

Proteomics: Pushing Towards Single-Cell Resolution

Nikolai Slavov, Ph.D., Northeastern University College of Engineering; Abhishek D. Garg, Ph.D., University of Leuven

Poster/Presentation

Identifying and Analyzing Tumor Subtypes Using Custom Morphology Markers for NanoString GeoMx® Digital Spatial Profiler

Poster/Presentation

Precise Spatial Multiplexing of Protein Biomarkers for Immune Profiling in Tissue Samples with ChipCytometry™

Webinar

Efficient and Flexible Spatial Multiplexing: Assay Development Guidelines for ChipCytometry™

Karen Kwarta, Canopy Biosciences

App Note/Tech Note

Using the ROSALIND Platform to Accelerate Single-Cell Data Analysis

FAQ

Gene Expression Profiling: Evaluating RNA Quality from FFPE Samples

FAQ

Selecting a CRO Partner: Navigating Laboratory Accreditation

Publication

Microbeam Radiation Therapy Controls Local Growth of Radioresistant Melanoma and Treats Out-of-Field Locoregional Metastasis

Verdiana Trappetti, PhD, Marine Potez, PhD, Cristian Fernandez-Palomo, PhD, Vladislav Volarevic, Nahoko Shintani, PhD, Paolo Pellicioli, PhD, Alexander Ernst, PhD, David Haberthur, PhD, Jennifer M. Fazzari, PhD, Michael Krisch, PhD, Jean A. Laissue, MD, Robin L. Anderson, PhD, Olga A. Martin, PhD, and Valentin G. Djonov, MD

Webinar

ChipCytometry™ Multiplexing: Practical, Approachable, Spatial Biology

J. Spencer Schwarz, Canopy Biosciences

Webinar

The Persistence of (T Cell) Memory: Towards Cellular Therapy for Solid Tumors

Douglas R. Green, PhD, Chair, Department of Immunology, Co-Leader, Cancer Biology Program, St. Jude Children’s Research Hospital

Poster/Presentation

SITC 2022 – Precise spatial multiplexing in clinical breast tumor specimens with a 60-plex ChipCytometry assay

Poster/Presentation

SITC 2022 – Using Additional Morphology Markers in NanoString® GeoMx® Whole Transcriptome Atlas Assay to Assess NSCLC Tumor Subtypes

Poster/Presentation

ASHG 2022 – Custom morphology markers allow better tissue stratification to study tumor heterogeneity using NanoString® GeoMx® DSP Platform

Case Study

Profiling the Tumor Microenvironment of Neuroblastoma using ChipCytometry™

Publication

Modeling intercellular communication in tissues using spatial graphs of cells

David S. Fischer, Anna C. Schaar & Fabian J. Theis

Webinar

Realizing the Potential of Spatial Biology for a Noncanonical Model

Shaye Hagler, Ph.D., Canopy Biosciences

Webinar

Validating Antibodies for Increasingly Sensitive Quantitative Applications

Caleb Sutton, Ph.D., Canopy Biosciences

Webinar

NanoString GeoMx® as a Key Tool for Immuno-Oncology Drug Discovery

Jessica Runyon, MA, Canopy Biosciences

Webinar

Technique Talk: Developing Spatial Multiomic Maps

Webinar

Investigating Immune Regulation by Small Extracellular Vesicles to Attenuate Chronic Pain Using High-Plex Spatial Imaging

Xuan Luo, Department of Pharmacology and Physiology, Drexel University College of Medicine

Webinar

Comprehensive Gene Expression Profiling for Immuno-Oncology Applications Using the nCounter® Analysis Platform

Christian Nievera, Ph.D., Canopy Biosciences

Product Bulletin

ChipCytometry™ ZellSafe™ Chip Kits

Product Bulletin

ChipCytometry™ CellScape™ Chip Kits

Webinar

Spatial Profiling of Neuroscience Samples Unlocks Pathways to Neurodegenerative Diseases

Jessica Runyon, M.A, Canopy Biosciences

App Note/Tech Note

Discover Novel Predictive Biomarkers with GeoMx® DSP

Webinar

Generating Actionable Spatial Biology Data with CellScape™ Precise Spatial Multiplexing

J. Spencer Schwarz, Canopy Biosciences

Poster/Presentation

AGBT 2022 – Precise spatial multiplexing of immune cell diversity in clinical breast tumor specimens with ChipCytometry

Product Bulletin

ChipCytometry™ T Cell Assay Kit

Product Bulletin

ChipCytometry™ Spatial Immune Profiling Assay Kit

Webinar

Fast Track to Precise Spatial Multiplexing: ChipCytometry™ Assay Kits and Assay Development Guidelines

Karen Kwarta, Ph.D., Canopy Biosciences

App Note/Tech Note

Using the nCounter® Platform for High-Throughput Analysis in Neuroscience Applications

Webinar

Novel Opportunities to Extend the Clinical Potential of Microbeam Radiotherapy

Olga Martin, Ph.D., Institute of Anatomy, University of Bern

Publication

ChipCytometry™ for multiplexed detection of protein and mRNA markers on human FFPE tissue samples

Sebastian Jarosch, Jan Köhlen, Sabrina Wagner, Elvira D’Ippolito, and Dirk H. Busch

Poster/Presentation

Immunology 2022 – Precise Spatial Multiplexing of Immune Cell Diversity in Clinical Tumor Samples with ChipCytometry™

Webinar

Using the nCounter® Platform for High-Throughput Transcriptomics in Neuroscience Applications

Christian Nievera, Ph.D., Canopy Biosciences

Poster/Presentation

SITC 2021 – Precise Spatial Multiplexing for Immune Profiling in Non Small Cell Lung Cancer FFPE Samples with ChipCytometry™

Poster/Presentation

CYTO 2021 – Precise Spatial Multiplexing of Immune Populations in Human Colorectal Cancer FFPE Samples with ChipCytometry™

App Note/Tech Note

nCounter® Host Response Panel for Infectious Disease Research

Webinar

Spatial Biology in Physiology and Pathology

Elana Fertig, Ph.D., Johns Hopkins University | Sanjar Srivatsan, Ph.D., University of Washington

Webinar

Multi-omics Approaches for Neurobiology Research

Webinar

Capturing Heterogeneity: How Single Cell Analysis Reshapes Health and Disease Research

Timothy O'Sullivan, Ph.D, University of California, Los Angeles | Jacob Blum, Stanford University

Webinar

Human immune cell compartments in the spleen of humanized mice

Prof. Christian Münz, Institute of Experimental Immunology, University of Zürich

Webinar

Analysis of T cell subsets in human tissue using ChipCytometry™

Prof. Paul Klenerman, Oxford University

Webinar

The Influence of Rare Cells in the Nervous System

Sebastian Lewandowski, Ph.D, Karolinska University | Philip Hasel, Ph.D., NYU School of Medicine

Webinar

High-plex immune profiling of clinical PBMCs using ChipCytometry™ – Addressing challenges with clinical sample logistics

Tim Sindelar, M.S., Canopy Biosciences

Webinar

Autoantibodies against Type I IFN found to impact morbidity when infected with COVID-19

Jessica Runyon, M.A, Canopy Biosciences

Poster/Presentation

AACR 2022 – Precise Spatial Multiplexing for Immune Profiling in FFPE Tissues with ChipCytometry™

Webinar

Precise Spatial Multiplexing for Quantitative Single-Cell Phenotyping in Tissues

Thomas Campbell, Ph.D., Canopy Biosciences

FAQ

RNA-Seq or nCounter®? Key Considerations for Gene Expression Studies

App Note/Tech Note

Developing ROI Selection Markers for GeoMx® Digital Spatial Profiling

Product Bulletin

ROI Selection Markers and CRO Services for GeoMx® Digital Spatial Profiling

Webinar

Using Spatial Transcriptomics Platforms to Assess Immune Profiling and Enable Biomarker Discovery: NanoString® GeoMx® Case Studies

Jessica Runyon, M.A, Canopy Biosciences

Webinar

Seeing is Believing: The Power of ChipCytometry™ Multiplexing

J. Spencer Schwarz, M.S., CanopyBiosciences

Webinar

Multiplexed Imaging & Automated Signal Quantification

Sebastian Jarosch, M.Sc., Institute for Immunology, Technical University of Munich (TUM)

Webinar

A Spotlight on T Cell Exhaustion

Webinar

Spatial Fest 2022: Exploring the Landscape with ChipCytometry™

Thomas Campbell, Ph.D, Canopy Biosciences | Sebastian Jarosch, M.Sc., Technical University of Munich (TUM) | Sarah Harris, Bristol Myers Squibb | Rachel Maddux, Ph.D, Bristol Myers Squibb | J. Spencer Schwarz, M.S., Canopy Biosciences

App Note/Tech Note

Optimizing Collection of Clinical Blood Samples for ChipCytometry™

Publication

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan P. Abo, Kaiko Kunii, Kristy G. Kuplast-Barr, Bin Gui, Alvin Z. Lu, Jennifer R. Molina, Elena Minissale, Kerren K. Swinger, Tim J. Wigle, Danielle J. Blackwell, Christina R. Majer, Yue Ren, Mario Niepel, Zacharenia A. Varsamis, Sunaina P. Nayak, Ellen Bamberg, Jan-Rung Mo, W. David Church, Ahmed S.A. Mady, Jeff Song, Luke Utley, Patricia E. Rao, Timothy J. Mitchison, Kevin W. Kuntz, Victoria M. Richon, and Heike Keilhack

Publication

Stimulatory MAIT cell antigens reach the circulation and are efficiently metabolised and presented by human liver cells

Martin J. Lett, Hema Mehta, Adrian Keogh, Tina Jaeger, Maxime Jacquet, Kate Powell, Marie-Anne Meier, Isabel Fofana, Hassan Melhem, Jürg Vosbeck, Gieri Cathomas, Andres Heigl, Markus H. Heim, Emanuel Burri, Kirsten D. Mertz, Jan Hendrik Niess, Otto Kollmar, Christoph J. Zech, Robert Ivanek, Urs Duthaler, Paul Klenerman, Deborah Stroka, Magdalena Filipowicz Sinnreich

Publication

Relationship Between Coronary Atheroma, Epicardial Adipose Tissue Inflammation, and Adipocyte Differentiation Across the Human Myocardial Bridge

Tracey McLaughlin, Ingela Schnittger, Anna Naggy, Elizabeth Zanley, Yue Xu, Yanqui Song, Koen Nieman, Jennifer A. Tremmel, Damini Dey, Jack Boyd, Harold Sacks

App Note/Tech Note

Antibody Validation for ChipCytometry™

Publication

Multiplexed imaging and automated signal quantification in formalin-fixed paraffin-embedded tissues by ChipCytometry™

Sebastian Jarosch, Jan Köhlen, Rim S.J. Sarker, Katja Steiger, Klaus-Peter Janssen, Arne Christians, Christian Hennig, Ernst Holler, Elvira D'Ippolito, and Dirk H. Busch

App Note/Tech Note

Selecting a Laboratory to Support Your Clinical Trial

Product Bulletin

ChipCytometry™ Assay Catalog

Product Bulletin

CRO Services for Spatial Transcriptomics

App Note/Tech Note

Rare Cell Discovery with ChipCytometry™

Poster

Novartis — ChipCytometry™ identifies the presence of uncommon B-cell subsets in inflamed tonsils associated with autoimmunity

Publication

Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis

Lennart M Roesner, Annice Heratizadeh, Gabriele Begemann, Petra Kienlin, Susanne Hradetzky, Margarete Niebuhr, Britta Eiz-Vesper, Christian Hennig, Gesine Hansen, Véronique Baron-Bodo, Philippe Moingeon, Thomas Werfel