Canopy
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Neuroinflammation Panel

Human and Mouse

The Neuroinflammation panels from NanoString are designed to rapidly analyze important aspects of neuroimmune interactions for a complete view of the complex interplay between immune and nervous systems. Each panel provides a comprehensive evaluation of the pathways, processes and cell types that are involved in inflammation.

Benefits

01

For research of neurodegenerative disease, traumatic brain injury, psychiatric disorders, neuropathic pain, CNS infection, and others.

02

Comprehensive assessment of 23 neuroinflammation pathways and processes.

03

Unique cell typing analysis feature measures the relative abundance of 19 CNS and peripheral immune cells.

04

Gene expression profiling for neuroimmune interactions and response to drug treatment.

Details & data

CNS and Peripheral Immune Cell Profiling

Genes included in the Neuroinflammation Panels provide unique cell profiling data for measuring the relative abundance of 19 central nervous system and peripheral immune cell types in a single sample. The table below summarizes each cell type represented by gene content in the panel qualified through biostatistical approaches and selected literature in the field of neuroinflammation research.

 

Cell ClassificationCell TypeHuman GenesMouse Genes
CNS CellsNeurons66
Micorglia66
Astorcytes88
Oligodendrocytes1515
Endothelial Cells99
Peripheral Immune CellsB cells77
Dendritic cells22
Exhausted CD844
Macrophages44
T cells66
CD8 T cells22
Neutrophils53
Mast Cells44
Cytotoxic cells98
Treg11
NK CD56dim cells23
NK cells22
CD45+ cells11
Th1 cells11

 

Neuroinflammation Panel Functional Annotations

Functional annotations for 23 pathways and processes were assigned across the genes in the Neuroinflammation Panels. The 23 pathways and processes represent three core themes of neuroinflammation: immunity and inflammation, neurobiology and neuropathology, and metabolism and stress.

 

Immunity and Inflammation
The role of innate immunity in many neurological disorders is now widely accepted in the research world although the relative contributions of these processes to the progression and/or amelioration of these diseases is incompletely understood. Several key processes and pathways are assessed in this panel to provide a comprehensive view of the immune and inflammatory response in the nervous system.
NF-κBMicroglia functionInnate immune response
Adaptive immune responseCytokine signalingInflammatory signaling
Neurobiology and Neuropathology
Neuropathology research today requires a broad view of all the underlying aspects of neurological disorders and injury, including assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. There are 13 pathways and processes included in this panel to evaluate the impact of neuroinflammation and immune actions in the nervous system on neuropathology.
AngiogenesisApoptosisNeurons and neurotransmissionCell CycleAstrocyte function
Insulin signalingNotchDNA damageEpigenetic regulationWnt
Oligodendrocyte functionMatrix remodelingGrowth Factor Signaling
Metabolism and Stress
Metabolic dysfunction and stress have been shown to influence brain activity and disrupt CNS homeostasis and cognitive function by adopting neurotoxic functions. The genes selected for this panel are designed to assess important aspects of metabolism and stress that are known to impact neuroinflammation.
AutophagyCarbohydrate metabolismLipid metabolismCellular stress

Genes in panel

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