Myeloid Innate Immunity Panel
Human and Mouse
The nCounter Myeloid Innate Immunity panels are designed to encompass all aspects of the myeloid innate immune response for use in basic and translational studies. Each panel enables the quantitative and qualitative measurement of attributes of innate immune response by evaluating gene enrichment of genes involved in recruitment and activation of selected myeloid subtypes.
Details & data
Innate Immunity Myeloid Cells
Genes included in the Myeloid Innate Immunity Panel were chosen based on their abundance/presence in the target cell and their ability to discern activation, polarization and effector phenotypes related to malignancy or infection. The table below gives a description of different myeloid cell types and the number of genes in the human or mouse panel that are reported to be associated with these cells based on the current literature.
|Cell Type||Immune Regulatory Function||Human Genes||Mouse Genes|
|Macrophage||Adaptive Immune System Activation and Suppression||333||332|
|Dendritic Cell||Adaptive Immune System Activation||262||264|
|Mast Cell||Immune modulation||152||147|
|IMCs||Strong immune suppression of both innate and adaptive immune system activity||173||169|
|TAM||Pro-tumor (Angiogenesis) and Anti-tumor. Variable dependent on tumor type||177||178|