Immune Cell Profiling Core Panel and Accompanying Modules

Curated Content for Immuno-oncology

The Immune Cell Profiling Core panel is designed to include key immuno-oncology protein targets and markers of immune cell types, including T cells, B cells, macrophages, NK cells, epithelia, and stroma. It also contains the controls needed to run any GeoMx DSP experiment. The 18 protein targets on the Core panel can be run as a stand-alone assay or combined with subsequent modules for a customized analysis of immune response in your experiment.

Modules

• IO Drug Target Module includes protein drug targets in development within the immuno-oncology space, including checkpoint molecules and metabolic mediators of immune function.
• Immune Activation Status Module includes additional checkpoint molecules that modulate T cell activation.
• Immune Cell Typing Module includes an expanded set of cell type markers to more deeply profile immune cell types covered in the Immune Cell Profiling Core and measure additional immune cell types, including T cell subsets.
• Pan-Tumor Module includes an expanded set of protein markers for detecting specific tumor types, including ER+/HER2+ breast tumors, hematopoietic, malignancies, and melanoma.
• Cell Death Module includes protein mediators of immunogenic and programed cell death.
• PI3K/AKT Signaling Module includes key proteins involved in PI3K/AKT signal transduction, and phosphorylated protein products that measure pathway activation.
• MAPK Signaling Module includes key proteins involved in MAPK signal transduction, and phosphorylated protein products that measure pathway activation.