Neuroinflammation Panel
Human and Mouse
The Neuroinflammation panels from NanoString are designed to rapidly analyze important aspects of neuroimmune interactions for a complete view of the complex interplay between immune and nervous systems. Each panel provides a comprehensive evaluation of the pathways, processes and cell types that are involved in inflammation.
Benefits
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Details & data
CNS and Peripheral Immune Cell Profiling
Genes included in the Neuroinflammation Panels provide unique cell profiling data for measuring the relative abundance of 19 central nervous system and peripheral immune cell types in a single sample. The table below summarizes each cell type represented by gene content in the panel qualified through biostatistical approaches and selected literature in the field of neuroinflammation research.
| Cell Classification | Cell Type | Human Genes | Mouse Genes |
|---|---|---|---|
| CNS Cells | Neurons | 6 | 6 |
| Micorglia | 6 | 6 | |
| Astorcytes | 8 | 8 | |
| Oligodendrocytes | 15 | 15 | |
| Endothelial Cells | 9 | 9 | |
| Peripheral Immune Cells | B cells | 7 | 7 |
| Dendritic cells | 2 | 2 | |
| Exhausted CD8 | 4 | 4 | |
| Macrophages | 4 | 4 | |
| T cells | 6 | 6 | |
| CD8 T cells | 2 | 2 | |
| Neutrophils | 5 | 3 | |
| Mast Cells | 4 | 4 | |
| Cytotoxic cells | 9 | 8 | |
| Treg | 1 | 1 | |
| NK CD56dim cells | 2 | 3 | |
| NK cells | 2 | 2 | |
| CD45+ cells | 1 | 1 | |
| Th1 cells | 1 | 1 |
Neuroinflammation Panel Functional Annotations
Functional annotations for 23 pathways and processes were assigned across the genes in the Neuroinflammation Panels. The 23 pathways and processes represent three core themes of neuroinflammation: immunity and inflammation, neurobiology and neuropathology, and metabolism and stress.
| Immunity and Inflammation | ||
|---|---|---|
| The role of innate immunity in many neurological disorders is now widely accepted in the research world although the relative contributions of these processes to the progression and/or amelioration of these diseases is incompletely understood. Several key processes and pathways are assessed in this panel to provide a comprehensive view of the immune and inflammatory response in the nervous system. |
||
| NF-κB | Microglia function | Innate immune response |
| Adaptive immune response | Cytokine signaling | Inflammatory signaling |
| Neurobiology and Neuropathology | ||||
|---|---|---|---|---|
| Neuropathology research today requires a broad view of all the underlying aspects of neurological disorders and injury, including assessment of neurotransmission, neuron-glia interactions, neuroplasticity, cell integrity, neuroinflammation, and metabolism. There are 13 pathways and processes included in this panel to evaluate the impact of neuroinflammation and immune actions in the nervous system on neuropathology. | ||||
| Angiogenesis | Apoptosis | Neurons and neurotransmission | Cell Cycle | Astrocyte function |
| Insulin signaling | Notch | DNA damage | Epigenetic regulation | Wnt |
| Oligodendrocyte function | Matrix remodeling | Growth Factor Signaling | ||
| Metabolism and Stress | |||
|---|---|---|---|
| Metabolic dysfunction and stress have been shown to influence brain activity and disrupt CNS homeostasis and cognitive function by adopting neurotoxic functions. The genes selected for this panel are designed to assess important aspects of metabolism and stress that are known to impact neuroinflammation. | |||
| Autophagy | Carbohydrate metabolism | Lipid metabolism | Cellular stress |
Genes in panel
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