V-PLEX Chemokine Panel 1 Human Kit

Human

Chemokines are small chemotactic cytokines with molecular weights around 8–10 kDa that are capable of inducing directed chemotaxis. Four cysteine residues in conserved locations result in a compact 3-dimensional structure. Based on the spacing of the first two cysteine residues, chemokines are divided into four families: CC chemokines, CXC chemokines, C chemokines, and CX3C chemokines, where C represents cysteine and X represents any other amino acid. Chemokines function by activating specific G protein-coupled receptors resulting in migration of inflammatory and non-inflammatory cells. The pro-inflammatory chemokines are responsible for migration of immune cells to the infection site, while the homeostatic chemokines are responsible for recruiting cells for tissue maintenance and development.

The Chemokine Panel 1 (human) Kit provides assay-specific components for the quantitative determination of eight CC chemokine (eotaxin, MIP-1β, eotaxin-3, TARC, MIP-1α, MCP-1, MDC, MCP-4) and two CXC chemokine assays (IP-10, IL-8). This kit may be used for the analysis of all or any combination of these chemokine biomarkers in cell culture supernatants, serum, plasma, and urine.

Dynamic range: 

  • Eotaxin: 3.26–1120 pg/mL
  • MIP-1β: 0.17–750 pg/mL
  • Eotaxin-3: 1.77–3750 pg/mL
  • TARC: 0.22–1120 pg/mL
  • IP-10: 0.37–500 pg/mL
  • MIP-1α:3.02–743 pg/mL
  • IL-8(HA): 95.6–43 400 pg/mL
  • MCP-1: 0.09–375 pg/mL
  • MDC: 1.22–7500 pg/mL
  • MCP-4: 1.69–469 pg/mL

Biomarkers in panel

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V-PLEX Chemokine Panel 1 Human Kit

$4,990.00

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